Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4389-4393, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-341848
Biblioteca responsable:
WPRO
ABSTRACT
This research is to study the relationship between HPLC fingerprints of Moutan Cortex, Paeoniae Radix Rubra and Paeoniae Radix Alba and their activity on lipopolysaccharide-induced acute lung injury. HPLC fingerprints of each extract of Moutan Cortex,Paeoniae Radix Rubra and Paeoniae Radix Alba were established by an optimized HPLC-MS method. The activities of all samples against protein and tumor necrosis a factor were tested by the model of lipopolysaccharide-induced acute lung injury. The possible relationship between HPLC-MS fingerprints and the activitieswere deduced by the Partial least squares regression analysis method. Samples were analyzed by HPLC-MS/MS to identify the major peaks. The results showed that each sample had some effect on acute lung injury. Four components with a lager contribution rate of efficacy were calculated by the research of spectrum-effect relationship. Moutan Cortex exhibited good activity on acute lung injury, and gallic acid, paeoniflorin, galloylpaeoniflorin and paeonol were the main effective components.
Texto completo:
Disponible
Bases de datos:
WPRIM (Pacífico Ocidental)
Medicinas Tradicionales:
Medicina Tradicional de Ásia
/
Medicina China
Asunto principal:
Acetofenonas
/
Farmacología
/
Medicamentos Herbarios Chinos
/
Química
/
Lipopolisacáridos
/
Cromatografía Líquida de Alta Presión
/
Ratas Wistar
/
Raíces de Plantas
/
Compuestos Bicíclicos Heterocíclicos con Puentes
/
Paeonia
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Artículo
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