Chemical constituents from stems of Lonicera japonica / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the chemical constituents from the ethanol extract of the stems of Lonicera japonica.</p><p><b>METHOD</b>The constituents were isolated and purified by repeated column chromatography on silica gel, Sephadex LH-20 and MCI HP-20. Their structures were identified by phsicochemical properties and spectroscopic analysis.</p><p><b>RESULT</b>Thirteen compounds were isolated and identified as protocatechuic acid (1), caffeic acid (2), macranthoin G (3), esculetin (4), luteolin (5), quercetin (6), apigenin (7), luteolin-7-O-beta-D-glucopyranoside (8), isorhamnetin-7-O-beta-D-glucopyranoside (9), diosmetin-7-O-beta-D-glucopyranoside (10), rhoifolin (11), lonicerin (12), hydnocarpin D (13).</p><p><b>CONCLUSION</b>Compound 4, 7, 9-11 were isolated from this plant for the first time, while compound 13 was first reported flavanolignan from this genus Lonicera.</p>