Effect of kangquan recipe on basic fibroblast growth factor of prostate tissue in rats / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of Kangquan Recipe (KQR) on basic fibroblast growth factor (bFGF) in prostatic tissue of rats.</p><p><b>METHODS</b>Benign prostatic hyperplasia model rat was established by injecting testosterone after castration. After being administered with KQR by gastrogavage for 30 days, the model rats were killed and their abdominal lobe prostate glands were taken for determining the protein and mRNA expressions of bFGF using immunohistochemical method and RT-polymerase chain reaction (RT-PCR) respectively.</p><p><b>RESULTS</b>The expressions of bFGF and bFGF mRNA were significantly lower in the model rats being treated with high or medium dose of KQR than those in the untreated model rats (P < 0.05 or P < 0.01), but these indexes were insignificantly different between the model rats treated with low dose of KQR and untreated model rats (P > 0.05).</p><p><b>CONCLUSION</b>KQR can effectively decrease the expression of bFGF in prostatic tissue of experimental benign prostate hyperplasia model rats.</p>