Evaluation of hepatoprotective effect of wedelia calendulacea lees

ABSTRACT

The 11 fluid extract of Wedelia calendulacea Less. aerial part was used for the evaluation of the plant hepatoprotective effect. The results of the pharmacological studies included (1) Oxidative activity 83.1% (in vitro), (2) Decrease of malonyl dialdehyde in mouse liver 25.1%, (3) Decrease of the serum glutamate pyruvic transaminase level 34.1%, (4) Decrease of the concentration of bilirubin in mouse serum 10.4%, (5) Increase of the bile flow in mice 88.8%. Conclusion: W. calendulacea had a good hepatoprotective effect in mouse model.