Effect of saffron aqueous extract on the level of blood glucose in experimental diabetes mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 173-176, 2018.
Article
en Zh
| WPRIM
| ID: wpr-773779
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES@#To investigate the effects of saffron aqueous extract (SE) on blood glucose, lipid and pancreatic tissue in streptozocin-induced diabetes mice.@*METHODS@#Diabetes mellitus mice were established by intraperitoneal injection of streptozocin (60 mg/kg) for two consecutive days. The 30 well-established diabetes mice were randomly divided into three groups(=10)diabetic mellitus (DM) group, SE treated (SE) group and positive control (metformin hydrochloride, MH) group. Another ten normal mice were selected as normal control (NC) group. The mice in SE and MH groups were intragastrically administered with SE 100 mg/kg or MH 100 mg/kg once a day for 6 weeks, mice in DM and NC were given normal saline. The amount of food-intake, water consumption and body weight were measured weekly, the changes of the indicators including fasting blood glucose (FBG), oral glucose-tolerance test (OGTT), glycated serum protein (GSP), insulin (INS) and blood lipid were determined after 6 weeks of continuous administration. The pathologic changes in the pancreas tissues were detected by HE staining.@*RESULTS@#Compared with the normal control group, the amount of food-intake, water consumption, area under the curve, FBG, GSP, and total cholesterol (TC) were significantly increased, while fasting weight, INS and high density lipoprotein cholesterol (HDL-c) were dramatically decreased in DM group. Compared with DM group, the water consumption, FBG, area under the curve and TC in SE group were starkly declined with a notable elevation of HDL-c and INS. In addition, the biopsy from DM mice showed the structure of pancreas islet was destroyed and reduced, and vascular proliferation with irregular shape. The damaged pancreas was obviously repaired by giving SE.@*CONCLUSIONS@#The saffron aqueous extract had efficacy on blood glucose and blood lipids reduction, improvement on damaged pancreas in streptozocininduced diabetic mice, which suggested that saffron could be used for the treatment in diabetes.
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Bases de datos:
WPRIM
Asunto principal:
Farmacología
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Sangre
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Glucemia
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Extractos Vegetales
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Distribución Aleatoria
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Química
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Estreptozocina
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Crocus
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Diabetes Mellitus Experimental
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Quimioterapia
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2018
Tipo del documento:
Article