Relationship Between Rotavirus and TLRs and Research Progress of Traditional Chinese Medicine / 中国实验方剂学杂志

ABSTRACT

Rotavirus (RV) infection of human body is mainly colonized in human intestinal epithelial cells, which results in small intestinal epithelial cell damage, and then induces diarrhea, fever and other symptoms. It is one of the most common causes of infantile diarrhea. Toll-like receptors (TLRs), as a kind of pattern recognition receptors, play an important role in the host immune system after virus infection. After different viruses infect human body, various pathogens trigger the host immune response through TLRs, induce the release of various cytokines, and stimulate a series of inflammatory reactions, such as fever, cough and diarrhea, which may further lead to more serious adverse consequences. According to the findings, the anti-inflammatory and anti-viral mechanisms of various effective drugs developed for different pathogens may be closely related to the intervention of TLRs signaling pathway and the regulation of immune response. A large number of studies have shown that rotavirus infection can induce inflammation by affecting the expressions of related proteins and genes in Toll-like receptor 3 (TLR3) and Toll-like receptor 4 (TLR4) signal transduction pathways, stimulating the release of inflammatory cytokines and inducing inflammatory response. Some studies on the mechanism of drug treatment for rotavirus diarrhea also started with TLRs, but only a few clinical and experimental studies on traditional Chinese medicine(TCM) and rotavirus diarrhea involve TLRs signaling pathway. Therefore, this article will focus on the relationship between TLRs signaling pathway and different viral infections, especially with rotavirus infection, in three aspects:viral infection and TLRs signaling pathway, RV infection and TLRs signaling pathway, and the research of traditional Chinese medicine in the treatment of rotavirus diarrhea, in order to guide the clinical and experimental studies on the treatment of rotavirus diarrhea with TCM based on TLR3 and TLR4 signaling pathways.