Effects of salvianolic acid and notoginseng triterpenes on angiogenesis in EA-hy926 cells in vitro / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 254-257, 2013.
Article
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| WPRIM
| ID: wpr-812697
Biblioteca responsable:
WPRO
ABSTRACT
AIM@#To investigate the different effects of salvianolic acid and notoginseng triterpenes on proliferation, angiogenesis and expression of vascular endothelial growth factor in EA-hy926 cells in vitro.@*METHODS@#EA-hy926 cells were cultured in vitro. Salvianolic acid and notoginseng triterpenes at concentrations of 0.4, 0.8 and 1.2 mg·L(-1) were used to culture EA-hy926 cells. EA-hy926 cells in a blank control group were grown in culture solution only. Viability of cells was assessed by CCK-8, and after treated for 12 h, capillary-like structures were examined. After 24 h culture, the expression of VEGF was detected by real-time PCR.@*RESULTS@#Salvianolic acid at 0.4, 0.8 mg·L(-1), the same as notoginseng triterpenes, increased VEGF content in EA-hy926 cells. Expression of VEGF protein in the salvianolic acid at 1.2 mg·L(-1) group, was up-regulated as compared with notoginseng triterpenes group (P < 0.05).@*CONCLUSION@#Salvianolic acid and notoginseng triterpenes can promote EA-hy926 cell proliferation, angiogenesis and expression of VEGF protein. This analysis also provided evidence that salvianolic acid had the better effects as compared with notoginseng triterpenes.
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Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
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Medicina_china
Asunto principal:
Farmacología
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Triterpenos
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Medicamentos Herbarios Chinos
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Química
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Estenosis Coronaria
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Línea Celular Tumoral
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Células Endoteliales
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Factor A de Crecimiento Endotelial Vascular
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Proliferación Celular
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Quimioterapia
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2013
Tipo del documento:
Article