Evaluating therapeutic potential of coriander seeds and leaves (Coriandrum sativum L.) to mitigate carbon tetrachloride-induced hepatotoxicity in rabbits
Asian Pacific Journal of Tropical Medicine
; (12): 209-213, 2018.
Article
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| WPRIM
| ID: wpr-825835
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To evaluate the hepatic and renal protective potential of coriander seeds and leaves using animal feed model.Methods:Coriander seeds- and leaves-based sauces were administrated to normal (Study I) and carbon tetrachloride (2 mL/kg B.W.)-induced hepatotoxic rabbits (Study II). Hepatic and renal biomarkers like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, superoxide dismutase and catalase were measured.Results:Coriander leaves-based sauce exerted more decline (P<0.05) in serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels in the study II as 18.32%, 19.91% and 21.24%, respectively. While, hepatic superoxide dismutase and catalase levels were raised significantly (P<0.05) in both studies. Renal parameters also depicted positive impact by the provision of developed sauces.Conclusions:Coriander seeds and leaves based sauces are effective in alleviating the hepato/renal toxicity. The hepatoprotective effect of coriander leaves is more pronounced as compared to coriander seeds.
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Bases de datos:
WPRIM
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2018
Tipo del documento:
Article