Research thinking and strategy on overall biopharmaceutics classification system of Chinese materia medica composition / 中草药

ABSTRACT

With the development of the modern Chinese materia medica (CMM) preparation, the design of CMM preparation faces more and more problems. Chemical medicine preparation design is based on biopharmaceutical properties. However, the question that how to make CMM preparation dosage form design reasonable becomes one of the main problems and the most difficult problem to solve. Based on the wholism concept of traditional Chinese medicine, this paper summarizes the components of the source. Through the research in CMM composition for many years, combining with the design basis of chemical medicine preparations, this study put forward research thoughts that selecting representative elements of CMM component, performing component "divergence" data analysis, similarity analysis, the weight coefficient method, and the efficacy contribution coefficient method to characterize the whole property of CMM components, in order to provide scientific basis for CMM components preparation.