Study on Clinical Efficacy of Lianhua Qingke Granule in Treatment of Mild and Ordinary COVID-19 / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae
; (24): 29-34, 2020.
Article
en Zh
| WPRIM
| ID: wpr-873214
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To evaluate the clinical efficacy and safety of traditional Chinese medicine Lianhua Qingke granule (LH granule)in the treatment of coronavirus disease 2019(COVID-19).Method:
A randomized controlled method was used in this clinical study. The subjects were confirmed COVID-19 patients over 18 years old with cough symptoms,and the diagnosis is based on Diagnosis and Treatment Protocol for COVID-19 (Trial Version 6). The subjects were randomized to usual treatment (control group) or in combination with LH granule (1 bag,thrice daily) for 14 days. The primary endpoint was the rate of cough recovery.Result:
57 subjects were included in this study, including 25 in the control group and 32 in the observation group. The recovery rate of cough in observation group was 90.6%(29/32), which was significantly higher than 64.0%(16/25)in the control group (P<0.05). The effective time of cough treatment was significantly earlier than that of the control group (P<0.05), the median time to cough recovery was markedly shorter in treatment group (P<0.05). The recovery rate of expectoration in observation group was 94.7% (18/19), which was significantly higher than 57.1%(8/14)in the control group (P<0.05). The effective time of expectoration treatment was significantly earlier than that of the control group (P<0.05), and the median time to expectoration recovery was markedly shorter in treatment group (P<0.05). The improvement rate of CT in the observation group was 96.9% (31/32), which was significantly higher than 72% (18/25) in the control group (P<0.05). After treatment, the oxygenation index of the two groups increased in varying degrees, and the increase rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in the recovery rate of fever, fatigue, dry pharynx and sore throat between the observation group and the control group, and it showed that LH had a better improvement trend on the basis of usual treatment.Conclusion:
On the basis of routine treatment,LH can significantly improve the symptoms of cough and expectoration of COVID-19 patients, shorten the duration of cough and expectoration symptoms, reduce lung pathological damage, improve respiratory function, and improve the symptoms of fever, fatigue, dry pharynx and sore throat.
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Tipo de estudio:
Clinical_trials
/
Guideline
Idioma:
Zh
Revista:
Chinese Journal of Experimental Traditional Medical Formulae
Año:
2020
Tipo del documento:
Article