Chemical constituents of Psidium guajava and their antitumor and antifungal activities / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3877-3885, 2021.
Article
en Zh
| WPRIM
| ID: wpr-888112
Biblioteca responsable:
WPRO
ABSTRACT
Twenty-six compounds, including sixteen meroterpenoids(1-16), a triterpenoid(17), four terpenoid derivatives(18-21), and five aromatic compounds(22-26), were isolated from the leaves of Psidium guajava. Their structures were identified by spectroscopic analyses including NMR and MS. Compounds 21-26 were obtained from plants of Psidium for the first time. Based on the structure,(R)-2-ethylhexyl 2H-1,2,3-triazole-4-carboxylate(24 a), an α-glucosidase inhibitor recently isolated from Paramignya trimera, should be revised as compound 24. Meroterpenoids 1-16 were evaluated for their antitumor and antifungal activities. Meroterpenoids psiguajadial D(4), guapsidial A(5), 4,5-diepipsidial A(7), guadial A(14), and guadial B(15) showed cytotoxicities against five human tumor cell lines(HL-60, A-549, SMMC-7721, MCF-7, and SW-480), among which 5 was the most effective with an IC_(50) of 3.21-9.94 μmol·L~(-1).
Palabras clave
Texto completo:
1
Bases de datos:
WPRIM
Asunto principal:
Terpenos
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Extractos Vegetales
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Espectroscopía de Resonancia Magnética
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Hojas de la Planta
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Psidium
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Antifúngicos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2021
Tipo del documento:
Article