Polyphenols from Securidaca inappendiculata alleviated acute lung injury in rats by inhibiting oxidative stress sensitive pathways / 中草药·英文版
Chinese Herbal Medicines
; (4): 381-388, 2021.
Article
en Zh
| WPRIM
| ID: wpr-953636
Biblioteca responsable:
WPRO
ABSTRACT
Objective: Securidaca inappendiculata is a medicinal plant frequently used in the treatment of inflammatory diseases in south China. In this study, we aimed to explore its bioactive constituent which contributes to the anti-inflammatory activity. Methods: Polyphenol-enriched and polyphenol-deprived fractions (PRF and PDF, respectively) were separated from the ethanolic extract by HPD300 macroporous resin-based method, and their anti-inflammatory activities were investigated on a lipopolysaccharide (LPS)-induced acute lung injury (ALI) model in rats. The possible mechanism of action in alleviating acute inflammation was studied using RAW264.7 cells. Results: Both Folin-Ciocalteu and
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Bases de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Herbal Medicines
Año:
2021
Tipo del documento:
Article