Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
Biol. Res
; 51: 21, 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-950905
Biblioteca responsável:
CL1.1
ABSTRACT
OBJECTIVE: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. RESULTS: EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. CONCLUSION: These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Medicinas Tradicionais:
Medicina Tradicional de Ásia
/
Medicina Chinesa
Métodos Terapêuticos e Terapias MTCI:
Terapias Energéticas
Elementos de Sistemas Médicos:
Sistema de Diagnóstico
/
Sistema Terapêutico
Assunto principal:
Eletroacupuntura
/
Ácido Aspártico
/
Ácido Glutâmico
/
Hipocampo
/
Aprendizagem
/
Memória
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Center for Rehabilitation Technology/CN
/
Fujian University of Traditional Chinese Medicine/CN
/
National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology/CN
/
Southern Medical University/CN
/
TCM Rehabilitation Research Center of SATCM/CN
Similares
MEDLINE
...
LILACS
LIS