The ypT may better predict the efficacy of neoadjuvant chemoradiotherapy than tumor regression grade in locally advanced rectal cancer patients diagnosed ypT1-4N0 / El ypT puede predecir mejor la eficacia de la quimiorradioterapia neoadyuvante que el grado de regresión tumoral en pacientes con cáncer de recto localmente avanzado diagnosticados ypT1-4N0
Clin. transl. oncol. (Print)
; 26(4): 1012-1021, Abr. 2024. graf
Article
em En
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| ID: ibc-VR-64
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ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Purpose: This study aimed to assess the impact of ypT stage and tumor regression grade (TRG) on the long-term prognosis of patients with locally advanced rectal cancer (LARC) stage ypT1-4N0 after neoadjuvant chemoradiotherapy (NCRT). Methods: We retrospectively analyzed 585 patients with histologically diagnosed middle-low LARC (cT3-4 or cN + by pelvic MRI) from 2014 to 2019. All patients underwent NCRT, followed by total mesorectal excision. Disease-free survival (DFS) rates were compared among patients with different ypT stages and TRGs by KaplanMeier survival analysis. The chi-square test was used to analyze the relationship between clinicopathological or therapeutic factors and ypT stage. Results: The median follow‐up was 35.8 months (range 2.871.8 months). The 3-year DFS was 79.5%. A better 3-year DFS was achieved in patients with a pathologic complete response (94.0% vs. 74.3%, p < 0.001) and those in the ypT0-2 (86.5% vs. 66.6%, p < 0.001), ypN0 (85.0% vs. 60.2%, p < 0.001), and TRG0 + 1 (83.1% vs. 73.0%, p = 0.004) subgroups. A total of 309 patients (52.8%) achieved stage ypT1-4N0 after surgery. Among these patients, the ypT1-2N0 subgroup achieved a significantly higher 3-year DFS than the ypT3-4N0 subgroup (85.4% vs. 72.8%, p = 0.018); in contrast, the 3-year DFS did not significantly differ between the TRG1 and TRG2 + 3 subgroups (79.9% vs. 81.1%, p = 0.833). In the ypT1-2N0 or ypT3-4N0 subgroup, different TRG had no significant effect on failure patterns. Conclusions: For LARC patients with a ypT1-4N0 status after NCRT, ypT stage may be a more effective predictor of long-term prognosis than TRG.(AU)
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Base de dados:
IBECS
Assunto principal:
Atenção Primária à Saúde
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Esquizofrenia
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Fatores de Risco
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Pandemias
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Pacientes
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Penicilinase
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Peru
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Prognóstico
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Embolia Pulmonar
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Qualidade da Assistência à Saúde
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
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Systematic_reviews
País/Região como assunto:
Europa
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America do sul
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Peru
Idioma:
Es
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En
Revista:
An. pediatr. (2003. Ed. impr.)
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Rev. esp. cir. ortop. traumatol. (Ed. impr.)
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An. sist. sanit. Navar
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Aten. prim. (Barc., Ed. impr.)
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Clin. transl. oncol. (Print)
/
Clín. investig. ginecol. obstet. (Ed. impr.)
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Enferm. infecc. microbiol. clín. (Ed. impr.)
/
Gastroenterol. hepatol. (Ed. impr.)
/
Int. microbiol
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Med. clín (Ed. impr.)
Ano de publicação:
2022
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2023
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2024
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2021
Tipo de documento:
Article