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The ypT may better predict the efficacy of neoadjuvant chemoradiotherapy than tumor regression grade in locally advanced rectal cancer patients diagnosed ypT1-4N0 / El ypT puede predecir mejor la eficacia de la quimiorradioterapia neoadyuvante que el grado de regresión tumoral en pacientes con cáncer de recto localmente avanzado diagnosticados ypT1-4N0
Cui, Yujun; Liu, Xinzhi; Li, Shuai; Wang, Hongzhi; Xiang, Yirong; Zhang, Yangzi; Song, Maxiaowei; Geng, Jianhao; Liu, Zhiyan; Teng, Huajing.
Afiliação
  • Cui, Yujun; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Liu, Xinzhi; Peking University Cancer Hospital. Department of Gastrointestinal Surgery. Beijing. China
  • Li, Shuai; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Wang, Hongzhi; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Xiang, Yirong; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Zhang, Yangzi; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Song, Maxiaowei; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Geng, Jianhao; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Liu, Zhiyan; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
  • Teng, Huajing; Peking University Cancer Hospital. Department of Radiation Oncology. Beijing. China
Clin. transl. oncol. (Print) ; 26(4): 1012-1021, Abr. 2024. graf
Article em En | IBECS | ID: ibc-VR-64
Biblioteca responsável: ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Purpose: This study aimed to assess the impact of ypT stage and tumor regression grade (TRG) on the long-term prognosis of patients with locally advanced rectal cancer (LARC) stage ypT1-4N0 after neoadjuvant chemoradiotherapy (NCRT). Methods: We retrospectively analyzed 585 patients with histologically diagnosed middle-low LARC (cT3-4 or cN + by pelvic MRI) from 2014 to 2019. All patients underwent NCRT, followed by total mesorectal excision. Disease-free survival (DFS) rates were compared among patients with different ypT stages and TRGs by Kaplan–Meier survival analysis. The chi-square test was used to analyze the relationship between clinicopathological or therapeutic factors and ypT stage. Results: The median follow‐up was 35.8 months (range 2.8–71.8 months). The 3-year DFS was 79.5%. A better 3-year DFS was achieved in patients with a pathologic complete response (94.0% vs. 74.3%, p < 0.001) and those in the ypT0-2 (86.5% vs. 66.6%, p < 0.001), ypN0 (85.0% vs. 60.2%, p < 0.001), and TRG0 + 1 (83.1% vs. 73.0%, p = 0.004) subgroups. A total of 309 patients (52.8%) achieved stage ypT1-4N0 after surgery. Among these patients, the ypT1-2N0 subgroup achieved a significantly higher 3-year DFS than the ypT3-4N0 subgroup (85.4% vs. 72.8%, p = 0.018); in contrast, the 3-year DFS did not significantly differ between the TRG1 and TRG2 + 3 subgroups (79.9% vs. 81.1%, p = 0.833). In the ypT1-2N0 or ypT3-4N0 subgroup, different TRG had no significant effect on failure patterns. Conclusions: For LARC patients with a ypT1-4N0 status after NCRT, ypT stage may be a more effective predictor of long-term prognosis than TRG.(AU)
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Texto completo: 1 Base de dados: IBECS Assunto principal: Atenção Primária à Saúde / Esquizofrenia / Fatores de Risco / Pandemias / Pacientes / Penicilinase / Peru / Prognóstico / Embolia Pulmonar / Qualidade da Assistência à Saúde Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies / Systematic_reviews País/Região como assunto: Europa / America do sul / Peru Idioma: Es / En Revista: An. pediatr. (2003. Ed. impr.) / Rev. esp. cir. ortop. traumatol. (Ed. impr.) / An. sist. sanit. Navar / Aten. prim. (Barc., Ed. impr.) / Clin. transl. oncol. (Print) / Clín. investig. ginecol. obstet. (Ed. impr.) / Enferm. infecc. microbiol. clín. (Ed. impr.) / Gastroenterol. hepatol. (Ed. impr.) / Int. microbiol / Med. clín (Ed. impr.) Ano de publicação: 2022 / 2023 / 2024 / 2021 Tipo de documento: Article
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Texto completo: 1 Base de dados: IBECS Assunto principal: Atenção Primária à Saúde / Esquizofrenia / Fatores de Risco / Pandemias / Pacientes / Penicilinase / Peru / Prognóstico / Embolia Pulmonar / Qualidade da Assistência à Saúde Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies / Systematic_reviews País/Região como assunto: Europa / America do sul / Peru Idioma: Es / En Revista: An. pediatr. (2003. Ed. impr.) / Rev. esp. cir. ortop. traumatol. (Ed. impr.) / An. sist. sanit. Navar / Aten. prim. (Barc., Ed. impr.) / Clin. transl. oncol. (Print) / Clín. investig. ginecol. obstet. (Ed. impr.) / Enferm. infecc. microbiol. clín. (Ed. impr.) / Gastroenterol. hepatol. (Ed. impr.) / Int. microbiol / Med. clín (Ed. impr.) Ano de publicação: 2022 / 2023 / 2024 / 2021 Tipo de documento: Article