Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case
Arq. neuropsiquiatr
; 54(2): 288-92, jun. 1996. ilus, tab
Article
em En
| LILACS
| ID: lil-172053
Biblioteca responsável:
BR1.1
ABSTRACT
A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbance resolved within theree weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a sitill unreported feature of podophillin toxicity.
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Podofilina
/
Miopatias Mitocondriais
Idioma:
En
Revista:
Arq. neuropsiquiatr
Ano de publicação:
1996
Tipo de documento:
Article