Ketamine reduces lethality on the acute ammonia intoxication in mice / La ketamina reduce la letalidad de la intoxicación aguda producida por amonio en ratones
Invest. clín
; 37(2): 129-35, jun. 1996.
Article
em En
| LILACS
| ID: lil-199234
Biblioteca responsável:
VE1.1
ABSTRACT
Injection of large doses of ammonia (1.2 g/kg, i.p.) was used to induce acute toxicity in mice which was characterized by hyperresponsivenes, taquipnea, clonic and tonic seizures and dealth. Pretreatment with 20,40, or 80 mg/kg i.p. of ketamine increased 30 to 55 per cent survival rate. This pretreatment significantly retarded the beginning of the first tonic convulsió attenuating its intensity and delayed the time of the animal death; but did not alter onset of the first clonic seizures. These experiments may be an evidence that support the hypothesis that seizures due to hyperammonemia involve activation of excitatory amino acid receptors
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Base de dados:
LILACS
Assunto principal:
Intoxicação
/
Aminoácidos
/
Ketamina
/
Camundongos
Idioma:
En
Revista:
Invest. clín
Ano de publicação:
1996
Tipo de documento:
Article