Response surface methodology for optimization of production of lovastatin by solid state fermentation
Braz. j. microbiol
; Braz. j. microbiol;41(1): 164-172, Jan.-Mar. 2010. graf, tab
Article
em En
| LILACS
| ID: lil-531748
Biblioteca responsável:
BR32.1
ABSTRACT
Lovastatin, an inhibitor of HMG-CoA reductase, was produced by solid state fermentation (SSF) using a strain of Aspergillus terreus UV 1718. Different solid substrates and various combinations thereof were evaluated for lovastatin production. Wheat bran supported the maximum production (1458 ± 46 µg g-1 DFM) of lovastatin. Response surface methodology (RSM) was applied to optimize the medium constituents. A 2(4) full-factorial central composite design (CCD) was chosen to explain the combined effects of the four medium constituents, viz. moisture content, particle size of the substrate, di-potassium hydrogen phosphate and trace ion solution concentration. Maximum lovastatin production of 2969 µg g-1 DFM was predicted by the quadratic model which was verified experimentally to be 3004 ± 25 µg g-1 DFM. Further RSM optimized medium supplemented with mycological, peptone supported highest yield of 3723.4±49 µg g-1 DFM. Yield of lovastatin increased 2.6 fold as with compared to un-optimized media.
Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Lovastatina
/
Inibidores de Hidroximetilglutaril-CoA Redutases
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Fermentação
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Idioma:
En
Revista:
Braz J Microbiol
/
Braz. j. microbiol
/
Braz. j. microbiol. (Online)
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Brazilian journal of microbiology (Impresso)
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia