Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract in rats.

Rani, S; Ahamed, N; Rajaram, S; Saluja, R; Thenmozhi, S; Murugesan, T

Rani, S; Ahamed, N; Rajaram, S; Saluja, R; Thenmozhi, S; Murugesan, T.

Afiliação

Rani S; Department of Pharmaceutical Chemistry, Maharaji College of Pharmacy, Besant Nagar, Chennai, India.

J Ethnopharmacol ; 68(1-3): 315-9, 1999 Dec 15.

Article em En | MEDLINE | ID: mdl-10624894

ABSTRACT

ABSTRACT

A study was undertaken to evaluate the effect of methanolic extract of leaves of Clerodendrum phlomidis Linn. (MECP) (Family Verbenaceae) for its anti-diarrhoeal potential against several experimental models of diarrhoea in Wistar albino rats. MECP showed significant inhibitory activity against castor oil induced diarrhoea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastrointestinal motility in charcoal meal test in rats. The results obtained establish the efficacy and substantiated the folklore claim as an anti-diarrhoeal agent.

Assuntos

Antidiarreicos/uso terapêutico; Diarreia/tratamento farmacológico; Motilidade Gastrointestinal/efeitos dos fármacos; Extratos Vegetais/uso terapêutico; Folhas de Planta/química; Animais; Óleo de Rícino/toxicidade; Dinoprostona/toxicidade; Relação Dose-Resposta a Droga; Feminino; Masculino; Medicina Tradicional; Metanol/química; Ratos; Ratos Wistar; Solubilidade

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Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Extratos Vegetais / Folhas de Planta / Diarreia / Motilidade Gastrointestinal / Antidiarreicos Idioma: En Revista: J Ethnopharmacol Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Índia

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