[Biological activity and structure of antitumor compounds from Plantago media L]. / Plantago media L antitumor hatóanyagainak szerkezete és biológiai aktivitása.
Acta Pharm Hung
; 69(5): 232-9, 1999 Nov.
Article
em Hu
| MEDLINE
| ID: mdl-10652790
ABSTRACT
Tyrosine kinase inhibition and tumor growth inhibition activity of verbascoside and homoplantaginin are described. Both molecules proved to be equally significant inhibitors of isolated EGF-R tyrosine kinases, nevertheless their in vitro antiproliferative activity was variable in cellular assays. Their different inhibitory efficacies could be interpreted on the basis of conformational analysis and lipophilicity evaluation.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Fenóis
/
Plantago
/
Plantas Medicinais
/
Flavonoides
/
Glucosídeos
/
Antineoplásicos Fitogênicos
Idioma:
Hu
Revista:
Acta Pharm Hung
Ano de publicação:
1999
Tipo de documento:
Article