Diazepam and buspirone alter neuropeptide Y-like immunoreactivity in rat brain.
Neuropeptides
; 33(6): 542-9, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10657538
ABSTRACT
Neuropeptide Y-like immunoreactivity (NPY-LI) was investigated in naIve Sprague-Dawley rats subjected to acute, subchronic (7 days) or chronic (21 days) intraperitoneal treatment with diazepam (1 or 3 mg/kg once daily) or buspirone (1.5 or 5 mg/kg twice daily). NPY-LI was determined by radioimmunoassay in the amygdala, nucleus accumbens, hypothalamus and frontal cortex 24 h after the last dose of the drugs. Amygdala NPY-LI decreased after acute diazepam (3 mg/kg) or buspirone (1.5 mg/kg) and increased after subchronic treatment with both doses of diazepam and after chronic buspirone (1.5 mg/kg) treatment. Both diazepam and buspirone given in subchronic and chronic doses decreased NPY-LI levels in the nucleus accumbens. Hypothalamic NPY-LI changed only after chronic treatment it decreased after diazepam and increased after buspirone (5 mg/kg). NPY-LI content in the frontal cortex decreased after subchronic diazepam (3 mg/kg) treatment and slightly increased after buspirone. The study has shown that both diazepam and buspirone affect NPY-LI levels in rats. These results suggest that the NPY system in the amygdala and nucleus accumbens is implicated in the anxiolytic effects of the drugs studied.
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Base de dados:
MEDLINE
Medicinas Complementares:
Homeopatia
Assunto principal:
Ansiolíticos
/
Química Encefálica
/
Buspirona
/
Receptores de Neuropeptídeo Y
/
Diazepam
Idioma:
En
Revista:
Neuropeptides
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Polônia