Assay for citrovorum factor (NSC-3590) in the presence of methotrexate (NSC-740).
Cancer Chemother Rep
; 59(5): 935-7, 1975.
Article
em En
| MEDLINE
| ID: mdl-1081908
ABSTRACT
Treatment of certain malignancies with high-dose methotrexate/citrovorum factor rescue has recently been adopted as an effective regimen. A microbiologic assay capable of detecting citrovorum factor in the presence of massive amounts of methotrexate has been developed using a strain of Pediococcus cerevisiae resistant to methotrexate. The assay described in this paper is an inexpensive and rapid method of studying the distribution kinetics of citrovorum factor.
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Base de dados:
MEDLINE
Assunto principal:
Metotrexato
/
Leucovorina
Idioma:
En
Revista:
Cancer Chemother Rep
Ano de publicação:
1975
Tipo de documento:
Article