Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat.
Pathol Int
; 50(6): 480-5, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10886724
ABSTRACT
S-100 proteins (S100) are characterized by calcium-binding ability with two structural EF hands. Several S100 are expressed in cardiomyocytes and thought to play a crucial role in calcium signaling. To examine whether the expression of S100 is a response to detectable myocardial damage or regeneration, we investigated, immunohistochemically, the expression of S100A4 and S100A11 in the isoproterenol (ISP)-treated rat heart. Definite expression of S100A4 and S100A11 was demonstrated in normal cardiomyocytes, and their staining patterns were enhanced in the ISP-treated rat heart, suggesting the possible involvement of S1-A4 and S100A11 in ISP-induced myocardial damage.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas S100
/
Cardiomegalia
/
Isoproterenol
Idioma:
En
Revista:
Pathol Int
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão