Effect of Withania somnifera on 20-methylcholanthrene induced fibrosarcoma.
J Exp Clin Cancer Res
; 19(2): 165-7, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10965813
ABSTRACT
Administration of an extract from the root of the plant Withania somnifera (20mg/dose/animal i.p) was found to inhibit the 20-methylcholanthrene induced sarcoma development in mice and increase the life span of tumour bearing animals. Administration of Withania could inhibit the lipid peroxide formation (152 nanomoles/mg protein) (P<0.01) compared with control (198 nanomoles/mg protein). Withania could increase the GSH level (7.7 micromoles/mg protein) which was lowered in control tumour bearing animals (3.96 micromoles/mg protein). GST level was also significantly increased (451 micromoles/min/mg protein) (P<0.001) in Withania treated animals compared to control animals (205 micromoles/min/mg protein). All the animals in the control group developed sarcoma by the 80th day of carcinogen administration. Only 3 animals in the Withania treated group developed sarcoma by the 105th day. In control animals the survival rate was 40% but in the Withania treated group the survival rate was 100% after 15 weeks of carcinogen treatment. These results indicate that Withania could inhibit 20-methylcholanthrene induced sarcoma development in mice.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Solanaceae
/
Fibrossarcoma
/
Antineoplásicos Fitogênicos
Idioma:
En
Revista:
J Exp Clin Cancer Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Índia