Boswellic acids in the palliative therapy of children with progressive or relapsed brain tumors.
Klin Padiatr
; 212(4): 189-95, 2000.
Article
em En
| MEDLINE
| ID: mdl-10994549
ABSTRACT
19 children and adolescents with intracranial tumors received a palliative therapy with H 15 at a maximum dose of 126 mg/kg BW/day. All patients had previously been treated with conventional therapy. No side effects were observed during a median 9 months application. The recently reported antiedematous effect of H 15 was documented by MRI in one patient with a peritumoral edema, thus sparing steroid therapy with its typical side effects. Five/19 children reported an improvement of their general health status; this might be a psychological effect of hope for tumor response during palliative care. Three/17 patients with malignant tumors showed a mainly transient improvement of neurological symptoms such as pareses and ataxia. Three further patients showed an increased muscular strength and one cachectic patient achieved a weight gain. These improvements might be attributed to the antiedematous effect of H 15. Because of the palliative situation of these patients, H 15 application was performed without prior rebiopsy for histological evaluation. Overlapping effects with a previous radiotherapy or chemotherapy may have occurred. An antiproliferative effect cannot be stated. To prevent an uncritical use of H 15, further studies with prospective central documentation have to be initiated to evaluate the clinical indications for H 15 in palliative therapy, optimal dosage and duration of application.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Triterpenos
/
Neoplasias Encefálicas
/
Anti-Inflamatórios não Esteroides
/
Glioma
/
Fitoterapia
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Observational_studies
Idioma:
En
Revista:
Klin Padiatr
Ano de publicação:
2000
Tipo de documento:
Article