n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro-inflammatory mediators in Type 2 diabetes mellitus.
Diabet Med
; 18(1): 51-8, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11168342
ABSTRACT
AIMS:
To examine the effect of n-3 polyunsaturated fatty acid supplements on the monocyte surface expression of adhesion molecules involved in proatherogenic monocyte-endothelial interactions, and on pro-inflammatory mediators in Type 2 diabetes mellitus.METHODS:
Twenty-nine subjects with Type 2 diabetes and 21 controls without diabetes were studied. Monocyte expression of leucocyte function-associated antigens 1 and 3, intercellular adhesion molecule-1, and the major histocompatibility complex class II molecule HLA-DR were measured using a laser flow cytometric method. Supplementation with 2.08 g n-3 fatty acids for 21 days was undertaken and measurements repeated. Plasma soluble adhesion molecule concentrations, plasminogen activator inhibitor-1 activity and antigen and pro-inflammatory mediators (cysteinyl leukotriene and monocyte leukotriene B4) were also measured.RESULTS:
Groups did not differ in monocyte expression of adhesion molecules or HLA-DR, or in leukotriene production although plasma soluble adhesion molecule concentrations were higher in the diabetes groups (P<0.05). n-3 fatty acid supplementation influenced neither the expression of these molecules nor plasma soluble adhesion molecule concentrations or leukotriene production.CONCLUSIONS:
This study does not support increased monocyte adhesion molecule expression or abnormal monocyte production of pro-inflammatory mediators as mechanisms for increased atherogenic risk in Type 2 diabetes. Cardioprotective actions of n-3 fatty acids may not be mediated through these mechanisms.
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Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Ácidos Graxos Ômega-3
/
Antígeno-1 Associado à Função Linfocitária
/
Molécula 1 de Adesão Intercelular
/
Antígenos CD58
/
Suplementos Nutricionais
/
Diabetes Mellitus Tipo 2
País/Região como assunto:
Europa
Idioma:
En
Revista:
Diabet Med
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Reino Unido