Phenylamides of 1-phenyl (or methyl)-5-benzamidopyrazole-4-carboxylic acid as vratizolin analogs with analgesic and antiinflammatory activities.
Arch Pharm (Weinheim)
; 334(5): 153-6, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11413820
ABSTRACT
A number of phenylamides of 5-benzamidopyrazole-4-carboxylic acid were prepared in 50-80% yields from 1-phenyl (or methyl)-6-phenylpyrazolo[3,4-d]1,3-oxazin-4(1H)-ones and aniline derivatives. All the compounds were tested for their analgesic and antiinflammatory activities, as well as for their ulcerogenic potential and acute toxicity. Some derivatives, when compared to phenylbutazone, proved more active in the tests for analgesic and antiexudative activities, but less active in the carrageenin paw oedema test. The compounds proved to posses marginal or no ulcerogenic effect, as well as low systemic toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Mediadores da Inflamação
/
Analgésicos
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Itália