Estrogen and related compounds: biphasic dose responses.
Crit Rev Toxicol
; 31(4-5): 503-15, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11504177
ABSTRACT
This article documents and quantitatively assesses the capacity of estrogen, phytoestrogens, and antiestrogens to affect biphasic dose-response relationships in animal/human models and across a broad range of cell types, affecting multiple endpoints. The range of endpoints displaying such biphasic dose responses includes plasminogen activation, oxytocin secretion, angiogenesis, cell proliferation, bone growth, monocyte chemotaxis, secretion of various cytokines, and other effects. The quantitative features of the dose response relationships revealed that the magnitude of the stimulatory responses was typically less than twofold, whereas the stimulatory responses were markedly variable ranging from about 5- to 10(6)-fold. Mechanistic explanations of the biphasic responses are addressed.
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Base de dados:
MEDLINE
Assunto principal:
Moduladores de Receptor Estrogênico
/
Estrogênios
/
Estrogênios não Esteroides
/
Homeostase
/
Isoflavonas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Crit Rev Toxicol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos