Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia.
J Ethnopharmacol
; 77(2-3): 183-8, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11535362
ABSTRACT
Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-alpha) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro.
Buscar no Google
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Flavonoides
/
Extratos Vegetais
/
Isquemia Encefálica
/
Fármacos Neuroprotetores
/
Flavanonas
/
Fitoterapia
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2001
Tipo de documento:
Article