Comparison of efficacy of ginger with various antimotion sickness drugs.
Clin Res Pr Drug Regul Aff
; 6(2): 129-36, 1988.
Article
em En
| MEDLINE
| ID: mdl-11538042
ABSTRACT
UNLABELLED Ginger and several other medications were compared with scopolamine and d-amphetamine for effectiveness in prevention of motion sickness. METHODS:
Double-blind techniques were used. The subjects were given the medications two hours before they were rotated in a chair making head movements until a symptom total short of vomiting was reached. Standardized N.A.S.A. techniques were used for speed of rotation and end-point of motion sickness.RESULTS:
The three doses of ginger were all at the placebo level of efficacy. Amitriptyline, ethopropazine and trihexyphenidyl increased the tolerated head movements but the increase was not statistically significant. Significant levels of protection were produced by dimenhydrinate, promethazine, scopolamine and d-amphetamine. Protection was further increased by combination of these latter drugs with d-amphetamine. Efficacy was greatest as the dose was increased.CONCLUSIONS:
The medication of choice in this study was scopolamine 0.6 mg with d-amphetamine 10 mg. This combination provided good protection with acceptable side effects.Palavras-chave
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Plantas Medicinais
/
Enjoo devido ao Movimento
/
Dextroanfetamina
/
Antieméticos
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Clin Res Pr Drug Regul Aff
Ano de publicação:
1988
Tipo de documento:
Article