Diabetic ketoacidosis and hypogonadotropic hypogonadism in association with transfusional hemochromatosis in a man with beta-thalassemia major.
J Formos Med Assoc
; 100(7): 492-6, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11579617
ABSTRACT
We report a 23-year-old man with beta-thalassemia major and transfusional hemochromatosis, which manifested as diabetic ketoacidosis and hypogonadotropic hypogonadism. This unusual presentation of diabetic ketoacidosis in hemochromatosis has rarely been reported. Magnetic resonance imaging of the abdomen showed decreased signal intensity in the liver, spleen, and pancreas. In addition, the pituitary gland also showed heterogeneous low signal intensity, compatible with hemochromatosis. He was treated with insulin supplements and pulsatile human chorionic gonadotropin administration. Clinical improvement was noted after hormone replacement. Intensive iron chelation therapy was given to prevent cardiac complications, and to restore his gonadal function. During follow-up, the patient experienced improvement in libido and sexual potency.
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Base de dados:
MEDLINE
Assunto principal:
Cetoacidose Diabética
/
Talassemia beta
/
Reação Transfusional
/
Hemocromatose
/
Hipogonadismo
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
J Formos Med Assoc
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Taiwan