Efficacies of BMS 284756 against penicillin-sensitive, penicillin-resistant, and quinolone-resistant pneumococci in experimental meningitis.
Antimicrob Agents Chemother
; 46(1): 184-7, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11751131
ABSTRACT
BMS 284756 penetrated well into inflamed meninges (44% +/- 11%) and produced good bactericidal activity (-0.82 +/- 0.22 Delta log(10) CFU/ml. h) in the treatment of experimental meningitis in rabbits due to a penicillin-sensitive strain. BMS 284756 monotherapy had a greater potency than the standard regimen of ceftriaxone and vancomycin (-0.49 +/- 0.08 Delta log(10) CFU/ml. h) against a penicillin-resistant strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, BMS 284756 showed good bactericidal activity (-0.52 +/- 0.12 Delta log(10) CFU/ml. h). The antibacterial activity of BMS 284756 was confirmed by time-killing assays over 8 h in vitro.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Streptococcus pneumoniae
/
Quinolonas
/
Fluoroquinolonas
/
Indóis
/
Meningite Pneumocócica
/
Anti-Infecciosos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Suíça