Maternal-fetal transport kinetics of copper, selenium, magnesium and iron in perfused human placental lobule: in vitro study.
Mol Cell Biochem
; 231(1-2): 9-14, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11952171
ABSTRACT
Transport characteristics of certain inorganic elements such as copper, magnesium, selenium and iron have been studied in maternal-fetal direction in normal pregnancies, using in vitro perfusion of isolated placental lobules. Copper, selenium, magnesium and iron salts corresponding to twice physiological concentrations were injected as a 100 microl bolus, into the maternal arterial perfusate. Serial perfusate samples were collected from venous outflows for a study period of 5 min. Concentrations of various inorganic elements and their transport kinetics were determined. Transport fractions of copper, selenium, magnesium and iron averaged 0.14, 0.19, 0.06 and 0.23% of maternal load respectively. The pharmacokinetic parameters such as area under the curve, clearance, elimination constant, and time for maximum response showed some significant differences between the various elements. We speculate that copper and selenium share the same transport pathway along a concentration gradient in maternal-fetal direction, while for iron and magnesium, active transport plays a predominant role for element transfer across the human placental membrane.
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Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Selênio
/
Cobre
/
Ferro
/
Magnésio
/
Troca Materno-Fetal
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Kuait