Effect of batroxobin on expression of neural cell adhesion molecule in temporal infarction rats and spatial learning and memory disorder.
J Tradit Chin Med
; 21(4): 294-8, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-12014135
ABSTRACT
The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.
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Base de dados:
MEDLINE
Assunto principal:
Batroxobina
/
Moléculas de Adesão Celular Neuronais
/
Infarto Cerebral
/
Transtornos da Memória
Idioma:
En
Revista:
J Tradit Chin Med
Ano de publicação:
2001
Tipo de documento:
Article