Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.
J Ethnopharmacol
; 82(1): 19-22, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12169400
ABSTRACT
The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously fed with cholesterol (25 mg/kg b.w.) for 30 days caused lowering in the lipids and apoprotein levels of VLDL and LDL in experimental animals. The LLA of this drug is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acids excretion and enhanced plasma lecithin cholesterol acyltransferase activity.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Phyllanthus
/
Hiperlipidemias
/
Lipídeos
/
Fitoterapia
/
Hipolipemiantes
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Índia