[Effectiveness of Vitex agnus-castus preparations]. / Zur Wirksamkeit von Vitex agnus castus-Präparaten.
Wien Med Wochenschr
; 152(15-16): 364-72, 2002.
Article
em De
| MEDLINE
| ID: mdl-12244880
The prolactin-inhibiting effect of ACF-preparations, which is due to dopaminergic activities, has been shown in humans too and gives a pharmacological rationale for the clinical effects observed in the different indications (2, 11, 25, 26, 35, 41). Confirmation of efficacy in the treatment of mastalgia has been best endorsed by two recently published double-blind studies conducted according to the principles of GCP (14, 41). One double-blind study, several open and postmarketing surveillance studies have shown that the premenstrual syndrome, or individual symptoms, can be influenced positively (3, 6, 7, 9, 19, 21, 37). Design shortcomings in a second double-blind study should be eliminated in future studies in this indication to improve the body of evidence (18). Hither to there has been one controlled double-blind study of cycle disorders in the case of corpus luteum insufficiency with significant results and a number of non-controlled open studies (1, 4, 15, 16, 20, 24, 26, 27, 32, 35, 36). The high success rates in the open studies indicate therapeutic effects, and it should be possible to reproduce these results under double-blind conditions. The success rates on fertility disorders should be confirmed in controlled double-blind studies (10, 33, 34).
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Extratos Vegetais
/
Vitex
/
Doenças dos Genitais Femininos
/
Fitoterapia
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Idioma:
De
Revista:
Wien Med Wochenschr
Ano de publicação:
2002
Tipo de documento:
Article