The role of soluble interleukin-4 receptor and interleukin-5 antibody in preventing late-phase allergy-induced eustachian tube dysfunction.
Otolaryngol Head Neck Surg
; 127(3): 169-76, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12297806
ABSTRACT
OBJECTIVES:
We investigated the role of soluble interleukin (IL)-4 receptors (sIL-4R) and IL-5 antibodies (IL-5Ab) in preventing allergic eustachian tube dysfunction (ETD) and middle ear effusion (MEE). STUDYDESIGN:
Brown-Norway rats were sensitized to ovalbumin (OVA) and challenged transtympanically. Two groups of rats received either IL-4R or IL-5Ab transtympanically 1 hour before challenge. Three additional groups were used as controls. Following the second transtympanic challenge, the ventilatory and clearance functions of the eustachian tube (ET) were assessed at 0, 2, and 8 hours. Histology was prepared using cut paraffin sections stained with hematoxylin and eosin.RESULTS:
sIL-4R-pretreated rats showed no significant changes in ventilatory or clearance functions of the ET or inflammatory changes in ET mucosa, whereas IL-5Ab pretreatment showed significant late ventilatory and clearance dysfunction as well as inflammatory mucosal changes.CONCLUSION:
These data demonstrate that the late-phase allergic inflammatory response that leads to subsequent formation of ETD and MEE is prevented by pretreatment with sIL-4R and, more modestly, with IL-5Ab.
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Base de dados:
MEDLINE
Assunto principal:
Otite Média com Derrame
/
Interleucina-5
/
Receptores de Interleucina-4
/
Modelos Animais de Doenças
/
Tuba Auditiva
/
Hipersensibilidade Tardia
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos