[Effects of Nao-Yi-An granule on activity of cytochrome c oxidase in hippocampus of experimental intracerebral hemorrhagic rats].
Hunan Yi Ke Da Xue Xue Bao
; 25(6): 542-4, 2000 Dec 28.
Article
em Zh
| MEDLINE
| ID: mdl-12516399
ABSTRACT
OBJECTIVE:
To explore the neuronal protective effects of a traditional Chinese medicine complex Nao-Yi-An granule(NYA) on experimental intracerebral hemorrhage(ICH) in rats.METHODS:
Eighty collagenase-induced ICH rats were used. At 12 h, 24 h, 2 d, 4 d, 7 d, cytochrome c oxidase(CO) activity was measured with histochemistry combined with gray scale scanning. Pyramidal cell(PC) counting was also employed following Nissl's staining.RESULTS:
The CO activities in NYA-treated group were less than those in model control group, and the neuronal loss was less in NYA-treated group than that in model control group.CONCLUSIONS:
The neuronal protective mechanism of NYA following ICH may be related with its maintaining activity of cytochrome c oxidase, which contributes to improving cellular aerobic metabolism and increasing energy supply for cells.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Medicamentos de Ervas Chinesas
/
Hemorragia Cerebral
/
Complexo IV da Cadeia de Transporte de Elétrons
/
Fármacos Neuroprotetores
/
Hipocampo
Idioma:
Zh
Revista:
Hunan Yi Ke Da Xue Xue Bao
Ano de publicação:
2000
Tipo de documento:
Article