Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.
Biol Pharm Bull
; 26(2): 166-9, 2003 Feb.
Article
em En
| MEDLINE
| ID: mdl-12576675
ABSTRACT
Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.
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Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Triptofano Hidroxilase
/
Núcleos da Rafe
/
Serotonina
/
Paeonia
Idioma:
En
Revista:
Biol Pharm Bull
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Coréia do Sul