[Clinical study on effect of Agkistrodon antithrombogenase in auxiliary treatment of rheumatoid arthritis].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 22(3): 166-8, 2002 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-12585096
ABSTRACT
OBJECTIVE:
To explore the clinical effect of Agkistrodon antithrombogenase (AAT) in the treatment of rheumatoid arthritis (RA) and its possible mechanism.METHODS:
Besides the conventional non-steroid anti-inflammatory agents and disease-modifying anti-rheumatic drug, patients were treated supplementally with intravenous injection of AAT. The intracutaneous test showed allergic to AAT patients were treated with Salvia injection and taken as control group. Changes of related clinical indexes in the two groups were observed.RESULTS:
After 3 weeks treatment, condition of patients in both groups were improved clinically in joint swollen index, joint tenderness index, morning stiffness time, pain assessment (VAS) and health assessment questionnaire (HAQ) on daily life activity as well as ESR level (P < 0.05 or P < 0.01), with the VAS, HAQ and fibrinogen levels more significantly improved than those of control (P < 0.05 or P < 0.01), and the total effective rate higher in the AAT treated group than those in the control group (P < 0.05).CONCLUSION:
AAT has good effect on easing clinical symptoms of RA possibly through anti-inflammation and improving the microcirculation with less toxic and adverse reaction, so is worthy of recommendation.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Artrite Reumatoide
/
Ancrod
/
Anti-Inflamatórios não Esteroides
/
Venenos de Crotalídeos
Tipo de estudo:
Guideline
/
Observational_studies
Idioma:
Zh
Revista:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Ano de publicação:
2002
Tipo de documento:
Article