The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.
Neuron
; 37(4): 649-61, 2003 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-12597862
ABSTRACT
The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neurons adjacent to the third ventricle between the dorsal, ventral, paraventricular, and arcuate hypothalamic nuclei. These neurons send efferents onto key hypothalamic circuits, including those producing neuropeptide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC) products, and corticotropin-releasing hormone (CRH). Within the hypothalamus, ghrelin bound mostly on presynaptic terminals of NPY neurons. Using electrophysiological recordings, we found that ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH). We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Sistema Nervoso Central
/
Hormônios Peptídicos
/
Metabolismo Energético
/
Homeostase
/
Hipotálamo
/
Rede Nervosa
Idioma:
En
Revista:
Neuron
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos