A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.
Arch Pathol Lab Med
; 127(4): e181-5, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12683897
ABSTRACT
A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.
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Base de dados:
MEDLINE
Assunto principal:
Hormônios Peptídicos
/
Leiomiossarcoma
/
Neoplasias Hepáticas
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Arch Pathol Lab Med
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos