Effect of ginseng radix on c-Fos expression in the hippocampus of streptozotocin-induced diabetic rats.
J Pharmacol Sci
; 91(2): 149-52, 2003 Feb.
Article
em En
| MEDLINE
| ID: mdl-12686759
ABSTRACT
Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased c-Fos expression in the CA regions of the hippocampus was observed in STZ-induced diabetes, and administration of Ginseng radix enhanced the STZ-induced inhibition of c-Fos expression both dose- and duration-dependently. These results suggest that hyperglycemia-induced suppression of Fos expression may trigger the diabetes-induced disruption of hippocampal information processing and that Ginseng radix may alleviate this diabetes-induced disturbance in hippocampal functions.
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Base de dados:
MEDLINE
Medicinas Complementares:
Homeopatia
Assunto principal:
Genes fos
/
Diabetes Mellitus Experimental
/
Panax
/
Hipocampo
Idioma:
En
Revista:
J Pharmacol Sci
Ano de publicação:
2003
Tipo de documento:
Article