Choto-san prevents occurrence of stroke and prolongs life span in stroke-prone spontaneously hypertensive rats.
Am J Chin Med
; 31(1): 79-85, 2003.
Article
em En
| MEDLINE
| ID: mdl-12723757
ABSTRACT
The effects of long-term oral administration of choto-san (diao-teng-san in Chinese) extract on the occurrence of stroke and life span were investigated in stroke-prone spontaneously hypertensive rats (SHR-SPs). Twenty-four rats were ramdomized into three groups. From 8 weeks of age, 0.1% and 0.3% choto-san groups were given water containing 0.1% (150 mg/kg/day) and 0.3% (450 mg/kg/day) choto-san extract, respectively. A control group was given only water. The mean survival times of the control group, 0.1% and 0.3% choto-san groups were 122.1, 159.8 and 176.8 days, respectively. The percent survivals of both the 0.1% and 0.3% choto-san groups were significantly enhanced compared to the control (Kaplan-Meier analysis followed by log-rank test; 0.1% choto-san p < 0.05; 0.3% choto-san p < 0.05). Furthermore, the cumulative percent occurrence of neurological and behavioral signs accompying stroke in the 0.3% choto-san group was significantly inhibited compared to the control (p < 0.05). These results suggested that choto-san prevents the occurrence of stroke and prolongs the life span of SHR-SPs.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Vasodilatadores
/
Medicamentos de Ervas Chinesas
/
Acidente Vascular Cerebral
/
Hipertensão
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Am J Chin Med
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão