Non-nucleoside inhibitors of HIV reverse transcriptase: screening successes--clinical failures.
Drug Des Discov
; 8(4): 255-63, 1992 Jul.
Article
em En
| MEDLINE
| ID: mdl-1280169
ABSTRACT
A little less than two years ago, the first report describing non-nucleoside inhibitors of HIV reverse transcriptase (RT) led to the high anticipation that a range of new drugs could soon be available for the treatment of AIDS. The intervening period has given rise to several such agents but recent clinical trial data has indicated this optimism to be premature. This short review seeks to trace the brief history of the drug discovery process and to assess whether there are lessons to be learnt from the episode.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
HIV
/
Inibidores da Transcriptase Reversa
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Drug Des Discov
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Reino Unido