Effects of vagus nerve stimulation on sleep-related breathing in epilepsy patients.
Epilepsia
; 44(7): 930-5, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12823576
ABSTRACT
PURPOSE:
To describe the effects of vagus nerve stimulation (VNS) on sleep-related breathing in a sample of 16 epilepsy patients.METHODS:
Sixteen adults with medically refractory epilepsy (nine men, seven women, ages 21-58 years) underwent baseline polysomnograms (PSGs). Three months after VNS therapy was initiated, PSGs were repeated. In addition, patient 7 had a study with esophageal pressure monitoring, and patient 1 had a continuous positive airway pressure (CPAP) trial.RESULTS:
Baseline PSGs One of 16 patients had an apnea-hypopnea index (AHI) >5 (6.8). Treatment PSGs Five of 16 patients had treatment AHIs >5. Respiratory events were more frequent during periods with VNS activation (on-time) than without VNS activation (off-time; p = 0.016). Follow-up studies Esophageal pressure monitoring in patient 7 showed crescendos in esophageal pressure during VNS activation, supporting an obstructive pattern. The CPAP trial of patient 1 showed that all respiratory events were associated with VNS stimulation at low CPAP levels. They were resolved at higher CPAP levels.CONCLUSIONS:
Treatment with VNS affects respiration during sleep and should be used with care, particularly in patients with preexisting obstructive sleep apnea. The AHI after VNS treatment remained <5 in the majority of patients and was only mildly elevated (<12) in five patients. In one patient, CPAP resolved VNS-related respiratory events.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Nervo Vago
/
Terapia por Estimulação Elétrica
/
Epilepsia Parcial Complexa
/
Epilepsia Generalizada
/
Polissonografia
/
Ventilação Pulmonar
/
Epilepsia Mioclônica Juvenil
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Epilepsia
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos