Synthesis and preliminary pharmacological assessment of novel 9-alkylamino substituted pyrimidino-[2,1-f]-purines.
Pol J Pharmacol Pharm
; 44(5): 487-503, 1992.
Article
em En
| MEDLINE
| ID: mdl-1297113
ABSTRACT
Two series of N9-alkylaminomethyl-, alkylpiperazino-, alkylpiperidino-substituted 1,3-dimethyl-(hexahydropyrimidino)- and (tetrahydropyrimidono)-[2,1-f]-purines were prepared and their physicochemical and pharmacological properties were described. The most active in central nervous system tests were the compounds with phenylpiperazinealkyl substituent i.e. 1,3-dimethyl-2,4-dioxo-9-[N1N4-(phenyl)-piperazinopropyl]-1, 3,6,7,8,9- hexahydropyrimidino-[2,1-f] purine 6a and its butyl and isobutyl homologs 9 and 12. The compounds depressed statistically significantly spontaneous locomotor and amphetamine activity and showed sedative, analgetic and hypothermizing properties.
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Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Comportamento Animal
/
Depressores do Sistema Nervoso Central
Idioma:
En
Revista:
Pol J Pharmacol Pharm
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Polônia