Transcatheter hepatic arterial chemoembolization using epirubicin-lipiodol: experimental and pharmacological evaluation.
Cancer Chemother Pharmacol
; 31 Suppl: S45-50, 1992.
Article
em En
| MEDLINE
| ID: mdl-1333908
ABSTRACT
The experimental and pharmacological characteristics of various formulations of an anticancer agent (epirubicin, EPI) and lipiodol were evaluated in vitro and in vivo. Three forms of EPI-lipiodol, i.e., an oil-in-water type of emulsion (O/W type), a water-in-oil type of emulsion (W/O type), and a suspension (S type), were prepared and investigated for their stability. An O/W-type emulsion using a stock solution of Iopamidol as the solvent for EPI was the most stable form in the stationary state in vitro. In 16 patients with malignant liver tumors (14 hepatocellular carcinomas and 2 liver metastases), the three forms of EPI-lipiodol were injected into the proper hepatic artery. The plasma EPI level was monitored periodically and analyzed pharmacokinetically. No significant difference in the pharmacokinetics of EPI was detected among the O/W, W/O, and S types.
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Base de dados:
MEDLINE
Assunto principal:
Epirubicina
/
Quimioembolização Terapêutica
/
Óleo Iodado
/
Neoplasias Hepáticas
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Japão