Evaluation of the analgesic activity of extracts of Miconia rubiginosa (Melastomataceae).
Phytomedicine
; 10(6-7): 606-9, 2003.
Article
em En
| MEDLINE
| ID: mdl-13678251
ABSTRACT
The analgesic effects of the hexane, methylene chloride and ethanol extracts of Miconia rubiginosa were evaluated in mice and rats using the acetic acid-induced writhing and hot plate tests. The extracts (100, 200 and 300 mg/kg body wt.) and indomethacin (5 mg/kg body wt.) produced a significant (p < 0.05 and p < 0.01) inhibition of acetic acid-induced abdominal writhing. These same extracts (200 mg/kg body wt.) showed a significant (p < 0.05) antinociceptive effect, lower than that produced by morphine (4 mg/kg body wt.). The fractionation of the methylene chloride extract yielded ursolic and oleanoic acids as the major compounds. Using only gas chromatography, it was possible to identify the following triterpenes in the hexane extract alpha-amyrin, beta-amyrin, lupeol and beta-sitosterol.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Dor
/
Extratos Vegetais
/
Melastomataceae
/
Analgésicos
/
Fitoterapia
Idioma:
En
Revista:
Phytomedicine
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Brasil