Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor.
Biochem Biophys Res Commun
; 313(2): 411-6, 2004 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-14684177
ABSTRACT
Amino acids can serve as regulatory molecules that modulate numerous cellular functions. Branched chain amino acids (BCAAs) are known to exert influences on cellular metabolism, amino acid transport, protein turn over, and gene expression. However, the mechanisms involved in the specific effect of BCAAs have not been clarified. BCAA supplementation therapy is a current treatment for patients with liver cirrhosis, therefore, specific BCAA activities should be examined. Hepatocyte growth factor (HGF) is considered to be a pleiotropic factor, and is reported to modulate gene expression and to stimulate the proliferation and functions of many cell types, including hepatocytes. A potential application of HGF for several types of diseases has been postulated. Here, we describe the potential of BCAAs as a therapeutic agent that acts through the induction of HGF production in the liver.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento de Hepatócito
/
Aminoácidos de Cadeia Ramificada
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão