Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine).
Acta Neurochir Suppl
; 86: 123-7, 2003.
Article
em En
| MEDLINE
| ID: mdl-14753419
ABSTRACT
Choto-san is a kampo medicine that is widely used in patients with cerebral infarction, but the details of its mechanism of action remain unclear. We examined the neuroprotective effects of Choto-san using an experimental cerebral ischemia model (i.e., a rat cardiac arrest model). We also investigated the ability of Choto-san to eliminate or inhibit the activity of free radicals. It was found that Choto-san significantly prevents delayed neuronal cell death after ischemic reperfusion. Electron spin resonance demonstrated that the formation of hydroxyl- and superoxide-DMPO spin adducts were inhibited by Choto-san. The results of this study indicated that Choto-san prevents delayed neuronal cell death in the hippocampal CA1 region after ischemia. Direct free radical scavenging activity is among the pharmacological effects of Choto-san.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
/
Medicina_japonesa
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Medicamentos de Ervas Chinesas
/
Isquemia Encefálica
/
Sequestradores de Radicais Livres
/
Fármacos Neuroprotetores
/
Medicina Kampo
Idioma:
En
Revista:
Acta Neurochir Suppl
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão